Talking to your doctor

Only you and your doctor know what treatment is right for you.

Here are some questions you can use to start a conversation:

Starting the conversation


Talk to Your Doctor About PIFELTRO™ (doravirine)

Starting the conversation


Questions You May Want to Ask Your Doctor About PIFELTRO™ (doravirine)

How will my treatment fit into my routine?

Side Effects of PIFELTRO™ (doravirine)

What side effects could I experience?

Weight Considerations

Could my HIV-1 treatment impact my weight?

PIFELTRO™ (doravirine) and Drug Interactions

Can I still take other medicine with my HIV-1 medicine?

How to Take PIFELTRO™ (doravirine)

Do I need to eat when I take my HIV-1 medicine?

About PIFELTRO™ (doravirine)

Are there other health risks my HIV or HIV-1 treatment could cause?

HIV-1 Treatment and Cholesterol

Can my HIV-1 treatment have a negative effect on my cholesterol?

Additional Treatment Considerations

An additional treatment consideration

Maintaining a healthy weight is an important part of taking care of your health and managing your HIV. You may have concerns about weight change. If you do, talk to your doctor.



Discussion Guide to Consider When Speaking to Your Doctor About PIFELTRO™ (doravirine)

Talking to your doctor

A discussion guide of questions you may want to consider when speaking with your doctor about PIFELTRO.

Download Digital Brochure for PIFELTRO™ (doravirine)

Digital brochure

Information on taking PIFELTRO, HIV-1 and your health, safety information, questions to ask your doctor and more.

DHHS treatment guidelines

The Department of Health and Human Services (DHHS) guidelines support changing HIV-treatment regimens for several reasons, including food requirements, side effects, and drug-drug interactions.

How to Take PIFELTRO™ (doravirine)

Food requirements

PIFELTRO™ (doravirine) and Drug Interactions

Potential drug interactions

Side Effects of PIFELTRO™ (doravirine)

Side effects

Safety information

Read more about side effects and additional safety information

Safety Information About PIFELTRO™ (doravirine)

Important Safety Information
  • Do not take PIFELTRO if you take any of the following medicines:
  • -carbamazepine
    -St. John’s wort
  • Ask your doctor or pharmacist if you are not sure if your medicine is one that is listed above. If you have taken any of the medicines in the past 4 weeks, talk to your doctor or pharmacist before starting PIFELTRO.
  • Changes in your immune system (Immune Reconstitution Syndrome) can happen when you start taking HIV-1 medicines. Your immune system may get stronger and begin to fight infections that have been hidden in your body for a long time. Tell your doctor right away if you start having new symptoms after starting your HIV-1 medicine.
  • The most common side effects of PIFELTRO include: nausea, dizziness, headache, tiredness, diarrhea, stomach (abdominal) pain, and abnormal dreams.
  • These are not all the possible side effects of PIFELTRO. For more information, ask your doctor or pharmacist.
  • Before starting PIFELTRO, tell your doctor about all your medical conditions, including if you are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. It is not known if PIFELTRO can harm your unborn baby. Do not breastfeed if you take PIFELTRO. Women with HIV should not breastfeed because their babies could be infected with HIV through their breast milk.
  • Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Some medicines interact with PIFELTRO. Keep a list of your medicines to show your doctor and pharmacist. Tell your doctor if you have taken rifabutin in the past 4 weeks. Do not start taking a new medicine without telling your doctor. Your doctor can tell you if it is safe to take PIFELTRO with those other medicines.
  • Take PIFELTRO every day exactly as your doctor tells you to take it. Take PIFELTRO 1 time each day, at about the same time every day.
  • Tell your doctor if you have taken rifabutin in the past 4 weeks.
  • If you take the medicine rifabutin during treatment with PIFELTRO, take PIFELTRO 2 times each day, about 12 hours apart, as prescribed by your doctor. You may not have enough doravirine in your blood if you take rifabutin during treatment with PIFELTRO.
  • Do not change your dose or stop taking PIFELTRO without talking to your doctor. Stay under a healthcare provider's care when taking PIFELTRO.
  • Take PIFELTRO on a regular dosing schedule as instructed by your doctor. Do not miss doses.
  • If you miss a dose of PIFELTRO, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the next dose at your regular time. Do not take 2 doses of PIFELTRO at the same time.
  • Get your PIFELTRO refilled from your doctor or pharmacy before you run out.
  • When your PIFELTRO supply starts to run low, get more from your healthcare provider or pharmacy. This is very important because the amount of virus in your blood may increase if the medicine is stopped for even a short time. The virus may develop resistance to PIFELTRO and become harder to treat.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call FDA at 1-800-FDA-1088.

Please read the Patient Information for PIFELTROTM (doravirine) and discuss it with your doctor. The physician Prescribing Information also is available.